NATOoperativeJacquesKristoffissummonedintoaction,onhisbirthday,totrackdownGalinaKonstantin,whohasscamperedoffwithanextremelyvaluableanddangeroustop-secretcargo.FindingGalinadoesn’ttakelong,andJacquesmustwrapupthemissionbyreturningGalinaandthecontrabandtohissuperiorsbytrain.Jacques’sphysicianwifeMadelineisn’thappyaboutthisturnofevents.Butsheseeshimoffatthetrainstationwiththecouple’steenagedaughterBaileyKristoffandsonEthanKristoff.Galina’sill-gottengainisthreevialsofSP-43,anultra-virulentstrainofsmallpox,culturedinfluorescentgreenserumthatcontainsseveralotherpathogens.Agroupofterrorists,ledbyMasonCole,intendtohijackthetrainandstealthevirusfortheirownends.ButstandingintheirwayisJacques.Thevirusendsupgettinglooseinthetrain’sventilationsystem.Unfortunately,Jacques’sfamilypickedthismomenttosurprisehimforhisbirthdaybysecretlytaggingalongfortheride.Jacquesbecomesaone-manarmyashefightstoprotecthisfamilyandtheotherpassengers,andstopColeandhisfollowers本条